Concerns during the critical appraisal of the results of meta-analysis

Systematic Review:Is the evidence useful? – Quality markers of systematic reviews with meta-analysis

Quality markers

Critical appraisal of a systematic review with meta-analysis - Randomised Controlled Trials

5 Quality Markers - Critical appraisal of a systematic review with meta-analysis - Randomised Controlled Trials (1:20)

1. Formulation of the research question

Quality Marker 1 (0:59)
Assessing the research question's formulation with "PICOT" (2:44)
Assessing whether the ‘right’ types of study design were included in the systematic review to answer the research question (1:23)

2. Identification of relevant primary research studies to include in the systematic review

Quality Marker 2 (1:00)
Bias in the published evidence base (2:24)
Searching (5:02)
Screening (1:31)
Selection (2:20)
A PRISMA-type flow diagram (2:48)

3. Quality assessment of the individual randomised controlled trials included in the systematic review

4. Extraction and presentation of data from the individual randomised controlled trials

Quality Marker 4 (0:48)
Extraction of data from randomised controlled trials in a systematic review with meta-analysis (2:45)
Presentation of data from randomised controlled trials in a systematic review with meta-analysis (0:37)

5. Statistical methods for meta-analysis

Quality Marker 5 (1:09)
Concerns during the critical appraisal of the results of meta-analysis (1:41)
Measurement of effect size, and precision and statistical significance of the effect estimate (12:13)
Precision of the effect estimate: confidence intervals (CIs) (2:27)
Statistical significance of the effect estimate: P value (1:08)
Heterogeneity (10:04)
Models of meta-analysis (3:28)
Sensitivity analysis (2:10)
Investigating the causes of heterogeneity (13:44)
Publication bias (2:37)

CASP Quiz

Critical appraisal of a systematic review with meta-analysis - Observational Studies

5 Quality Markers - Critical appraisal of a systematic review with meta-analysis - Observational Studies (1:11)

1. Formulation of the research question

Quality Marker 1 (0:54)
Assessing the research question’s formulation with the mnemonic ‘PECOT’ (2:41)
Assessing whether the ‘right’ types of study design were included in the systematic review to answer the research question (1:09)

3. Quality assessment of the individual observational studies included in the systematic review

Quality Marker 3 (2:18)
Quality assessment of observational studies – the Newcastle-Ottawa Scale (NOS) (1:18)

4. Extraction and presentation of data from the individual randomised controlled trials

Quality Marker 4 (0:47)
Extraction of data from observational studies in a systematic review with meta-analysis (2:40)

5. Statistical methods for meta-analysis

Quality Marker 5 (1:07)
Measures used to express the effect size or magnitude in a systematic review with meta-analysis (4:28)

CASP Quiz

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